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Anchoring and ordering NGS contig assemblies by population sequencing (POPSEQ).

Subsequent-generation whole-genome shotgun assemblies of advanced genomes are extremely helpful, however fail to hyperlink close by sequence contigs with one another or present a linear order of contigs alongside particular person chromosomes. Right here, we introduce a method based mostly on sequencing progeny of a segregating inhabitants that permits de novo manufacturing of a genetically anchored linear meeting of the gene area of an organism.
We reveal the ability of the method by reconstructing the chromosomal group of the gene area of barley, a big, advanced and extremely repetitive 5.1 Gb genome. We consider the robustness of the brand new meeting by comparability to a lately launched bodily and genetic framework of the barley genome, and to numerous genetically ordered sequence-based genotypic datasets. The tactic is unbiased of the necessity for any prior sequence assets, and can allow fast and cost-efficient institution of highly effective genomic data for a lot of species.
Subsequent-generation sequencing (NGS) as a diagnostic instrument for retinal degeneration reveals a a lot larger detection fee in early-onset illness.
Inherited retinal degeneration (IRD) is a typical explanation for visible impairment (prevalence ∼1/3500). There may be appreciable phenotype and genotype heterogeneity, making a particular prognosis very troublesome with out molecular testing. We investigated focused seize mixed with next-generation sequencing utilizing Nimblegen 12plex arrays and the Roche 454 sequencing platform to discover its potential for medical diagnostics in two frequent kinds of IRD, retinitis pigmentosa and cone-rod dystrophy. 50 sufferers (36 unknowns and 14 constructive controls) have been screened, and pathogenic mutations have been recognized in 25% of sufferers within the unknown, with 53% within the early-onset instances.
All sufferers with new mutations detected had an age of onset <21 years and 44% had a household historical past. Thirty-one % of mutations detected have been novel. A de novo mutation in rhodopsin was recognized in a single early-onset case with out a household historical past. Bioinformatic pipelines have been developed to establish possible pathogenic mutations and stringent standards have been used for task of pathogenicity. Evaluation of sequencing metrics revealed vital variability in seize effectivity and depth of protection.
We conclude that focused seize and next-generation sequencing are prone to be very helpful in a diagnostic setting, however sufferers with earlier onset of illness usually tend to profit from utilizing this technique. The mutation-detection fee means that many sufferers are prone to have mutations in novel genes.
Mining of public sequencing databases helps a non-dietary origin for putative overseas miRNAs: underestimated results of contamination in NGS.
The report that exogenous plant miRNAs are in a position to cross the mammalian gastrointestinal tract and exert gene-regulation mechanism in mammalian tissues has yielded loads of controversy, each within the public press and the scientific literature. Regardless of the preliminary enthusiasm, reproducibility of those outcomes was lately questioned by a number of authors. To investigate the causes of this unease, we looked for diet-derived miRNAs in deep-sequencing libraries carried out by ourselves and others. We discovered variable quantities of plant miRNAs in publicly obtainable small RNA-seq information units of human tissues.
In human spermatozoa, exogenous RNAs reached excessive, biologically meaningless ranges. Quite the opposite, plant miRNAs weren’t detected in our sequencing of human sperm cells, which was carried out within the absence of any identified sources of plant contamination. We designed an experiment to indicate that cross-contamination throughout library preparation is a supply of exogenous RNAs. These contamination-derived exogenous sequences even resisted oxidation with sodium periodate.

To check the idea that diet-derived miRNAs have been really contamination-derived, we sought within the literature for earlier sequencing studies carried out by the identical group which reported the preliminary discovering. We analyzed the spectra of plant miRNAs in a small RNA sequencing examine carried out in amphioxus by this group in 2009 and we discovered a really robust correlation with the plant miRNAs which they later reported in human sera.
Although contamination with exogenous sequences could also be simple to detect, cross-contamination between samples from the identical organism can go fully unnoticed, probably affecting conclusions derived from NGS transcriptomics.
Area interactions in E. coli SRP: stabilization of M area by RNA is required for efficient sign sequence modulation of NG area.
The E. coli protein, Fth, binds to 4.5S RNA by means of its M area to type the sign recognition particle (SRP). The opposite area of Fth (NG) is a GTPase, which binds and is coordinately regulated by its receptor, FtsY. We discover that the helical M area is inherently versatile. Binding of 4.5S RNA to Fth stabilizes the M area but has little obvious impact on the binding of sign peptides.
Sodium tungstate dihydrate |
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GK6152-500 | Glentham Life Sciences | 500 | 126.5 EUR |
Sodium tungstate dihydrate, 99+% |
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GX9903-1 | Glentham Life Sciences | 1 | 327.4 EUR |
Sodium tungstate dihydrate, 99+% |
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GX9903-250 | Glentham Life Sciences | 250 | 134.1 EUR |
Sodium tungstate |
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20-abx184826 | Abbexa |
|
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Sodium citrate dihydrate |
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GK0137-100G | Glentham Life Sciences | 100 g | 48 EUR |
Sodium citrate dihydrate |
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GK0137-1KG | Glentham Life Sciences | 1 kg | 73.2 EUR |
Sodium citrate dihydrate |
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GK0137-250G | Glentham Life Sciences | 250 g | 52.8 EUR |
Sodium citrate dihydrate |
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GK0137-500G | Glentham Life Sciences | 500 g | 62.4 EUR |
Sodium citrate dihydrate |
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GK0137-5KG | Glentham Life Sciences | 5 kg | 170.4 EUR |
Sodium citrate dihydrate |
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HY-B1610 | MedChemExpress | 1g | 142.8 EUR |
Sodium citrate dihydrate |
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GK0137-1 | Glentham Life Sciences | 1 | 32.4 EUR |
Sodium citrate dihydrate |
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GK0137-100 | Glentham Life Sciences | 100 | 11.3 EUR |
Sodium citrate dihydrate |
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GK0137-250 | Glentham Life Sciences | 250 | 16.4 EUR |
Sodium citrate dihydrate |
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GK0137-5 | Glentham Life Sciences | 5 | 116.3 EUR |
Sodium citrate dihydrate |
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GK0137-500 | Glentham Life Sciences | 500 | 22.4 EUR |
Sodium tartrate dihydrate |
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GK1687-1KG | Glentham Life Sciences | 1 kg | 129.6 EUR |
Sodium tartrate dihydrate |
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GK1687-250G | Glentham Life Sciences | 250 g | 67.2 EUR |
Sodium tartrate dihydrate |
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GK1687-500G | Glentham Life Sciences | 500 g | 88.8 EUR |
Tolmetin (sodium dihydrate) |
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HY-B1489 | MedChemExpress | 100mg | 142.8 EUR |
Sodium tartrate dihydrate |
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GK1687-1 | Glentham Life Sciences | 1 | 77.4 EUR |
Sodium tartrate dihydrate |
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GK1687-250 | Glentham Life Sciences | 250 | 25.3 EUR |
Sodium tartrate dihydrate |
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GK1687-500 | Glentham Life Sciences | 500 | 43.5 EUR |
Sodium tetrathionate dihydrate |
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GK8710-100G | Glentham Life Sciences | 100 g | 466.8 EUR |
Sodium nitroprusside dihydrate |
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GT2671-100G | Glentham Life Sciences | 100 g | 76.8 EUR |
Sodium nitroprusside dihydrate |
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GT2671-250G | Glentham Life Sciences | 250 g | 117.6 EUR |
Sodium nitroprusside dihydrate |
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GT2671-25G | Glentham Life Sciences | 25 g | 52.8 EUR |
Sodium nitroprusside dihydrate |
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GT2671-500G | Glentham Life Sciences | 500 g | 187.2 EUR |
Sodium nitroprusside dihydrate |
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SB0867 | Bio Basic | 50g | 84.01 EUR |
Sodium nitroprusside dihydrate |
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GT2671-100 | Glentham Life Sciences | 100 | 33.1 EUR |
Sodium nitroprusside dihydrate |
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GT2671-25 | Glentham Life Sciences | 25 | 15.7 EUR |
Sodium nitroprusside dihydrate |
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GT2671-250 | Glentham Life Sciences | 250 | 67.2 EUR |
Sodium nitroprusside dihydrate |
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GT2671-500 | Glentham Life Sciences | 500 | 125.1 EUR |
Sodium tetrathionate dihydrate |
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GK8710-100 | Glentham Life Sciences | 100 | 355.8 EUR |
Sodium molybdate dihydrate, 99.5% |
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GK4422-100G | Glentham Life Sciences | 100 g | 64.8 EUR |
Sodium molybdate dihydrate, 99.5% |
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GK4422-1KG | Glentham Life Sciences | 1 kg | 217.2 EUR |
Sodium molybdate dihydrate, 99.5% |
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GK4422-250G | Glentham Life Sciences | 250 g | 96 EUR |
Sodium molybdate dihydrate, 99.5% |
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GK4422-500G | Glentham Life Sciences | 500 g | 141.6 EUR |
Sodium molybdate dihydrate, 98% |
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GX5429-1KG | Glentham Life Sciences | 1 kg | 199.2 EUR |
Sodium molybdate dihydrate, 98% |
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GX5429-500G | Glentham Life Sciences | 500 g | 128.4 EUR |
Sodium molybdate dihydrate, 98% |
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GX5429-1 | Glentham Life Sciences | 1 | 134.4 EUR |
Sodium molybdate dihydrate, 98% |
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GX5429-500 | Glentham Life Sciences | 500 | 76.6 EUR |
Sodium molybdate dihydrate, 99.5% |
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GK4422-1 | Glentham Life Sciences | 1 | 150.4 EUR |
Sodium molybdate dihydrate, 99.5% |
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GK4422-100 | Glentham Life Sciences | 100 | 23.8 EUR |
Sodium molybdate dihydrate, 99.5% |
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GK4422-250 | Glentham Life Sciences | 250 | 49.9 EUR |
Sodium molybdate dihydrate, 99.5% |
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GK4422-500 | Glentham Life Sciences | 500 | 87.1 EUR |
Sodium dihydrogen phosphate dihydrate |
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GK8728-100G | Glentham Life Sciences | 100 g | 50.4 EUR |
Sodium dihydrogen phosphate dihydrate |
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GK8728-1KG | Glentham Life Sciences | 1 kg | 84 EUR |
Sodium dihydrogen phosphate dihydrate |
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GK8728-250G | Glentham Life Sciences | 250 g | 55.2 EUR |
Sodium dihydrogen phosphate dihydrate |
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GK8728-500G | Glentham Life Sciences | 500 g | 64.8 EUR |
Sodium dihydrogen phosphate dihydrate |
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GK8728-5KG | Glentham Life Sciences | 5 kg | 208.8 EUR |
Sodium dihydrogen phosphate dihydrate |
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GK8728-1 | Glentham Life Sciences | 1 | 39.4 EUR |
Sodium dihydrogen phosphate dihydrate |
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GK8728-100 | Glentham Life Sciences | 100 | 13 EUR |
Sodium dihydrogen phosphate dihydrate |
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GK8728-250 | Glentham Life Sciences | 250 | 15.9 EUR |
Sodium dihydrogen phosphate dihydrate |
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GK8728-5 | Glentham Life Sciences | 5 | 142.4 EUR |
Sodium dihydrogen phosphate dihydrate |
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GK8728-500 | Glentham Life Sciences | 500 | 23.8 EUR |
Sodium 4-aminosalicylate dihydrate |
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HY-I0447A | MedChemExpress | 5g | 192 EUR |
Sodium 4-aminosalicylate dihydrate |
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GM7502-25G | Glentham Life Sciences | 25 g | 57.6 EUR |
Sodium phosphate, monobasic, dihydrate |
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SB0879 | Bio Basic | 500g | 80.08 EUR |
Sodium 4-aminosalicylate dihydrate |
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GM7502-25 | Glentham Life Sciences | 25 | 17.8 EUR |
Sodium molybdate dihydrate, EP grade |
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GK1113-1KG | Glentham Life Sciences | 1 kg | 274.8 EUR |
Sodium molybdate dihydrate, EP grade |
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GK1113-500G | Glentham Life Sciences | 500 g | 172.8 EUR |
Sodium molybdate dihydrate, EP grade |
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GK1113-1 | Glentham Life Sciences | 1 | 197.7 EUR |
Sodium molybdate dihydrate, EP grade |
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GK1113-500 | Glentham Life Sciences | 500 | 112.7 EUR |
Sodium citrate, trisodium salt, dihydrate |
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CB0035 | Bio Basic | 500g | 73.78 EUR |
Sodium nitroprusside dihydrate, ACS grade |
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GX4924-100G | Glentham Life Sciences | 100 g | 92.4 EUR |
Sodium nitroprusside dihydrate, ACS grade |
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GX4924-250G | Glentham Life Sciences | 250 g | 151.2 EUR |
Sodium nitroprusside dihydrate, ACS grade |
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GX4924-25G | Glentham Life Sciences | 25 g | 62.4 EUR |
Sodium nitroprusside dihydrate, ACS grade |
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GX4924-100 | Glentham Life Sciences | 100 | 46.8 EUR |
Sodium nitroprusside dihydrate, ACS grade |
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GX4924-25 | Glentham Life Sciences | 25 | 21.4 EUR |
Sodium nitroprusside dihydrate, ACS grade |
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GX4924-250 | Glentham Life Sciences | 250 | 95 EUR |
Sodium Tartrate dibasic Dihydrate, 1 M, 100 ML |
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M-CSS-301 | MiTeGen | 100 ml | 133 EUR |
Description: Sodium Tartrate dibasic Dihydrate, 1 M, 100 ML |
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Lead tungstate, 99.9% |
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GX7052-100 | Glentham Life Sciences | 100 | 197 EUR |
Lead tungstate, 99.9% |
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GX7052-25 | Glentham Life Sciences | 25 | 101 EUR |
Zinc tungstate, 99.9% |
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GX2338-10 | Glentham Life Sciences | 10 | 113.1 EUR |
Zinc tungstate, 99.9% |
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GX2338-25 | Glentham Life Sciences | 25 | 195.6 EUR |
Zinc tungstate, 99.9% |
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GX2338-50 | Glentham Life Sciences | 50 | 278.8 EUR |
Dichloroisocyanuric acid sodium salt dihydrate |
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GK1784-100G | Glentham Life Sciences | 100 g | 56.4 EUR |
Dichloroisocyanuric acid sodium salt dihydrate |
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GK1784-1KG | Glentham Life Sciences | 1 kg | 112.8 EUR |
Dichloroisocyanuric acid sodium salt dihydrate |
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GK1784-250G | Glentham Life Sciences | 250 g | 64.8 EUR |
Dichloroisocyanuric acid sodium salt dihydrate |
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GK1784-500G | Glentham Life Sciences | 500 g | 84 EUR |
Dichloroisocyanuric acid sodium salt dihydrate |
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GK1784-50G | Glentham Life Sciences | 50 g | 50.4 EUR |
Dichloroisocyanuric acid sodium salt dihydrate |
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GK1784-1 | Glentham Life Sciences | 1 | 63.3 EUR |
Dichloroisocyanuric acid sodium salt dihydrate |
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GK1784-100 | Glentham Life Sciences | 100 | 16.6 EUR |
Dichloroisocyanuric acid sodium salt dihydrate |
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GK1784-250 | Glentham Life Sciences | 250 | 23.8 EUR |
Dichloroisocyanuric acid sodium salt dihydrate |
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GK1784-50 | Glentham Life Sciences | 50 | 13 EUR |
Dichloroisocyanuric acid sodium salt dihydrate |
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GK1784-500 | Glentham Life Sciences | 500 | 39.4 EUR |
Copper tungstate, 99.5% |
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GX9426-100 | Glentham Life Sciences | 100 | 262.3 EUR |
Copper tungstate, 99.5% |
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GX9426-25 | Glentham Life Sciences | 25 | 123.5 EUR |
Barium tungstate, 99.9% |
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GX1134-50 | Glentham Life Sciences | 50 | 198.7 EUR |
Lithium tungstate, 99.9% |
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GX5534-100 | Glentham Life Sciences | 100 | 215.1 EUR |
Lithium tungstate, 99.9% |
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GX5534-25 | Glentham Life Sciences | 25 | 107 EUR |
Calcium tungstate, 99+% |
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GX9049-100 | Glentham Life Sciences | 100 | 126.5 EUR |
Calcium tungstate, 99+% |
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GX9049-250 | Glentham Life Sciences | 250 | 246.1 EUR |
Rubidium tungstate, 99.9% |
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GX5881-10 | Glentham Life Sciences | 10 | 179.3 EUR |
Rubidium tungstate, 99.9% |
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GX5881-25 | Glentham Life Sciences | 25 | 311.3 EUR |
Manganese tungstate, 99.9% |
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GX4905-100 | Glentham Life Sciences | 100 | 304.8 EUR |
Manganese tungstate, 99.9% |
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GX4905-25 | Glentham Life Sciences | 25 | 125.1 EUR |
Magnesium tungstate, 99.9% |
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GX3912-100 | Glentham Life Sciences | 100 | 325.9 EUR |
Magnesium tungstate, 99.9% |
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GX3912-25 | Glentham Life Sciences | 25 | 146.2 EUR |
Strontium tungstate, 99.9% |
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GX0472-10 | Glentham Life Sciences | 10 | 101 EUR |
Strontium tungstate, 99.9% |
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GX0472-50 | Glentham Life Sciences | 50 | 233 EUR |
Riboflavin-5-phosphate, sodium salt, dihydrate |
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RD0472 | Bio Basic | 25g | 87.14 EUR |
Ammonium tungstate hydrate, 99% |
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GX9978-100 | Glentham Life Sciences | 100 | 150.4 EUR |
Ammonium tungstate hydrate, 99% |
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GX9978-25 | Glentham Life Sciences | 25 | 47.4 EUR |
JBS Tungstate Cluster Kit; contains 3 different clusters |
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M-PK-108 | MiTeGen | 10.5 mg | 178 EUR |
Description: JBS Tungstate Cluster Kit; contains 3 different clusters |
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di-Sodium hydrogen phosphate dihydrate |
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GK8671-100G | Glentham Life Sciences | 100 g | 46.8 EUR |
di-Sodium hydrogen phosphate dihydrate |
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GK8671-1KG | Glentham Life Sciences | 1 kg | 70.8 EUR |
di-Sodium hydrogen phosphate dihydrate |
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GK8671-250G | Glentham Life Sciences | 250 g | 51.6 EUR |
di-Sodium hydrogen phosphate dihydrate |
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GK8671-500G | Glentham Life Sciences | 500 g | 58.8 EUR |
di-Sodium hydrogen phosphate dihydrate |
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GK8671-5KG | Glentham Life Sciences | 5 kg | 141.6 EUR |
tri-Sodium Citrate Dihydrate, 1.6 M, 100 ML |
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M-CSS-319 | MiTeGen | 100 ml | 94 EUR |
Description: tri-Sodium Citrate Dihydrate, 1.6 M, 100 ML |
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Cidofovir dihydrate |
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B1238-10 | ApexBio | 10 mg | 129.6 EUR |
Description: Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis. |
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Cidofovir dihydrate |
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B1238-100 | ApexBio | 100 mg | 240 EUR |
Description: Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis. |
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Cidofovir dihydrate |
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B1238-25 | ApexBio | 25 mg | 157.2 EUR |
Description: Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis. |
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Cidofovir dihydrate |
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B1238-5.1 | ApexBio | 10 mM (in 1mL DMSO) | 129.6 EUR |
Description: Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis. |
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Quercetin, Dihydrate |
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1773-1000 | Biovision | each | 261.6 EUR |
Quercetin, Dihydrate |
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1773-250 | Biovision | each | 124.8 EUR |
Cidofovir dihydrate |
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C202-10MG | TOKU-E | 10 mg | 98.4 EUR |
Cidofovir dihydrate |
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C202-50MG | TOKU-E | 50 mg | 262.8 EUR |
Alvimopan dihydrate |
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A3163-10 | ApexBio | 10 mg | 512.4 EUR |
Description: Alvimopan dihydrate is a selective antagonist of opioid receptor with IC50 value of 1.7 nM.Opioid receptor is a G protein-coupled receptor with opioids as ligands. |
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Alvimopan dihydrate |
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A3163-5 | ApexBio | 5 mg | 343.2 EUR |
Description: Alvimopan dihydrate is a selective antagonist of opioid receptor with IC50 value of 1.7 nM.Opioid receptor is a G protein-coupled receptor with opioids as ligands. |
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Alvimopan dihydrate |
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A3163-5.1 | ApexBio | 10 mM (in 1mL DMSO) | 397.2 EUR |
Description: Alvimopan dihydrate is a selective antagonist of opioid receptor with IC50 value of 1.7 nM.Opioid receptor is a G protein-coupled receptor with opioids as ligands. |
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Alvimopan dihydrate |
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A3163-50 | ApexBio | 50 mg | 1399.2 EUR |
Description: Alvimopan dihydrate is a selective antagonist of opioid receptor with IC50 value of 1.7 nM.Opioid receptor is a G protein-coupled receptor with opioids as ligands. |
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Quercetin dihydrate |
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A2552-100 | ApexBio | 100 mg | 324 EUR |
Description: Quercetin Dihydrate is the dihydrate preparation of Quercetin, a ubiquitous natural flavonoid with antiproliferative properties. Quercetin is described to inhibit PLA2 and PI 3-kinase (IC50 = 3.8 microM), blocking the ATP binding site of this kinase and i |
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Quercetin dihydrate |
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A2552-25 | ApexBio | 25 mg | 150 EUR |
Description: Quercetin Dihydrate is the dihydrate preparation of Quercetin, a ubiquitous natural flavonoid with antiproliferative properties. Quercetin is described to inhibit PLA2 and PI 3-kinase (IC50 = 3.8 microM), blocking the ATP binding site of this kinase and i |
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Quercetin dihydrate |
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A2552-5.1 | ApexBio | 10 mM (in 1mL DMSO) | 157.2 EUR |
Description: Quercetin Dihydrate is the dihydrate preparation of Quercetin, a ubiquitous natural flavonoid with antiproliferative properties. Quercetin is described to inhibit PLA2 and PI 3-kinase (IC50 = 3.8 microM), blocking the ATP binding site of this kinase and i |
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Cidofovir (dihydrate) |
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HY-17438A | MedChemExpress | 10mg | 142.8 EUR |
Alvimopan (dihydrate) |
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HY-76657A | MedChemExpress | 50mg | 721.2 EUR |
Quercetin (dihydrate) |
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HY-N0146 | MedChemExpress | 100mg | 267.6 EUR |
Quercetin dihydrate |
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GP1387-100G | Glentham Life Sciences | 100 g | 132 EUR |
Quercetin dihydrate |
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GP1387-250G | Glentham Life Sciences | 250 g | 208.8 EUR |
Quercetin dihydrate |
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GP1387-25G | Glentham Life Sciences | 25 g | 74.4 EUR |
Quercetin dihydrate |
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GP1387-500G | Glentham Life Sciences | 500 g | 322.8 EUR |
Quercetin Dihydrate |
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TBZ2533 | ChemNorm | 20mg | Ask for price |
Phlorizin dihydrate |
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TBZ2935 | ChemNorm | 20mg | Ask for price |
Quercetin dihydrate |
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GP1387-100 | Glentham Life Sciences | 100 | 79.1 EUR |
Quercetin dihydrate |
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GP1387-25 | Glentham Life Sciences | 25 | 31.7 EUR |
Quercetin dihydrate |
|||
GP1387-250 | Glentham Life Sciences | 250 | 142.4 EUR |
Quercetin dihydrate |
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GP1387-500 | Glentham Life Sciences | 500 | 237.2 EUR |
Lisinopril dihydrate |
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B2132-250 | Biovision | each | 352.8 EUR |
Lisinopril dihydrate |
|||
B2132-50 | Biovision | each | 157.2 EUR |
Lisinopril dihydrate |
|||
B3290-5.1 | ApexBio | 10 mM (in 1mL DMSO) | 129.6 EUR |
Description: Lisinopril is a long-acting inhibitor of angiotensin converting enzyme (ACE) with IC50 value of 4.7nM [1].Lisinopril is a lysine analogue of MK 421. |
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Lisinopril dihydrate |
|||
B3290-50 | ApexBio | 50 mg | 153.6 EUR |
Description: Lisinopril is a long-acting inhibitor of angiotensin converting enzyme (ACE) with IC50 value of 4.7nM [1].Lisinopril is a lysine analogue of MK 421. |
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Lisinopril dihydrate |
|||
B3290-S | ApexBio | Evaluation Sample | 97.2 EUR |
Description: Lisinopril is a long-acting inhibitor of angiotensin converting enzyme (ACE) with IC50 value of 4.7nM [1].Lisinopril is a lysine analogue of MK 421. |
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Lisinopril (dihydrate) |
|||
HY-18206A | MedChemExpress | 500mg | 170.4 EUR |
Ceftibuten (dihydrate) |
|||
HY-B0698A | MedChemExpress | 10mM/1mL | 151.2 EUR |
Mildronate dihydrate |
|||
GW2470-10 | Glentham Life Sciences | 10 | 83.3 EUR |
Mildronate dihydrate |
|||
GW2470-25 | Glentham Life Sciences | 25 | 135.6 EUR |
Enalaprilat Dihydrate |
|||
B2204-10 | ApexBio | 10 mg | 164.4 EUR |
Description: Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. |
|||
Enalaprilat Dihydrate |
|||
B2204-100 | ApexBio | 100 mg | 351.6 EUR |
Description: Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. |
|||
Enalaprilat Dihydrate |
|||
B2204-50 | ApexBio | 50 mg | 235.2 EUR |
Description: Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. |
|||
Aminopterin dihydrate |
|||
GK2974-100MG | Glentham Life Sciences | 100 mg | 206.4 EUR |
Aminopterin dihydrate |
|||
GK2974-10MG | Glentham Life Sciences | 10 mg | 72 EUR |
Aminopterin dihydrate |
|||
GK2974-25MG | Glentham Life Sciences | 25 mg | 90 EUR |
Aminopterin dihydrate |
|||
GK2974-50MG | Glentham Life Sciences | 50 mg | 128.4 EUR |
Enalaprilat (dihydrate) |
|||
HY-B0231 | MedChemExpress | 100mg | 267.6 EUR |
Aminopterin dihydrate |
|||
GK2974-10 | Glentham Life Sciences | 10 | 30.1 EUR |
Aminopterin dihydrate |
|||
GK2974-100 | Glentham Life Sciences | 100 | 140.7 EUR |
Aminopterin dihydrate |
|||
GK2974-25 | Glentham Life Sciences | 25 | 45.1 EUR |
Aminopterin dihydrate |
|||
GK2974-50 | Glentham Life Sciences | 50 | 76.6 EUR |
Azithromycin Dihydrate |
|||
B1669-25 | ApexBio | 25 mg | 153.6 EUR |
Description: Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. |
|||
Azithromycin Dihydrate |
|||
B1669-5.1 | ApexBio | 10 mM (in 1mL DMSO) | 184.8 EUR |
Description: Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. |
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Azithromycin Dihydrate |
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B1669-50 | ApexBio | 50 mg | 224.4 EUR |
Description: Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. |
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Azithromycin dihydrate |
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A024-25MG | TOKU-E | 25 mg | 279.6 EUR |
Hydrindantin dihydrate |
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GK5212-10G | Glentham Life Sciences | 10 g | 93.6 EUR |
Hydrindantin dihydrate |
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GK5212-25G | Glentham Life Sciences | 25 g | 151.2 EUR |
Nonetheless, within the absence of the RNA, sign peptide binding ends in a world destabilization of Fth, which is prevented by binding of 4.5S RNA. Sign peptide binding to remoted NG area additionally causes a pronounced destabilization, implicating the NG area in direct recognition of sign peptide.
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