insulin signaling
BMP signaling agonist sb4 |
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T7799-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: BMP signaling agonist sb4 |
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BMP signaling agonist sb4 |
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T7799-1g | TargetMol Chemicals | 1g | Ask for price |
Description: BMP signaling agonist sb4 |
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BMP signaling agonist sb4 |
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T7799-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: BMP signaling agonist sb4 |
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BMP signaling agonist sb4 |
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T7799-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: BMP signaling agonist sb4 |
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BMP signaling agonist sb4 |
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T7799-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: BMP signaling agonist sb4 |
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Human Notch Signaling Pathway |
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HNOT-I | Real Time Primers | 1 set | 657.6 EUR |
Human Statin Signaling Library |
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HSTAT-I | Real Time Primers | 1 set | 657.6 EUR |
Hh Signaling Pathway Antagonist |
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1659-1 | Biovision | each | 216 EUR |
Rat Bdnf Signaling Primer Library |
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RBDNF-I | Real Time Primers | 1 set | 774 EUR |
Rat Gdnf Signaling Primer Library |
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RGDNF-I | Real Time Primers | 1 set | 774 EUR |
Mouse Ras Signaling Primer Library |
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MRAS-I | Real Time Primers | 1 set | 657.6 EUR |
Mouse p53 Signaling Primer Library |
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MTPS-I | Real Time Primers | 1 set | 540 EUR |
Mouse WNT Signaling Primer Library |
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MWNT-I | Real Time Primers | 1 set | 657.6 EUR |
Mouse BMP Signaling Primer Library |
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MBMP-I | Real Time Primers | 1 set | 657.6 EUR |
ER Signaling Protein Detection Set |
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PSI-1814 | ProSci | 1 Set | 752.1 EUR |
Description: The endoplasmic reticulum (ER) is an organelle composed of an interconnected network of tubules, vesicles and cisternae found in all eukaryotic cells. It is involved in several specialized processes such as protein translation, folding, and transport of proteins to be used in the cell membrane or secreted from the cell. Accumulation of malfolded proteins in the ER activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase, to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA, converting it to a potent UPR transcriptional activator. ER stress also causes the cleavage of ATF6, yielding a cytosolic fragment which migrates to the nucleus and together with XBP-1, activates transcription of UPR-responsive genes. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER.;;For images please see PDF data sheet |
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Human BMP Signaling Primer Library |
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HBMP-I | Real Time Primers | 1 set | 657.6 EUR |
Human MAP Kinase Signaling Library |
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HMAP-I | Real Time Primers | 1 set | 657.6 EUR |
Human Ras Signaling Primer Library |
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HRAS-I | Real Time Primers | 1 set | 657.6 EUR |
Human TNF Signaling Primer Library |
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HTNF-I | Real Time Primers | 1 set | 657.6 EUR |
Human p53 Signaling Primer Library |
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HTPS-I | Real Time Primers | 1 set | 540 EUR |
Human WNT Signaling Primer Library |
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HWNT-I | Real Time Primers | 1 set | 657.6 EUR |
Mouse Gdnf Signaling Primer Library |
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MGDNF-I | Real Time Primers | 1 set | 657.6 EUR |
Mouse Bdnf Signaling Primer Library |
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MBDNF-I | Real Time Primers | 1 set | 657.6 EUR |
Mouse CREB Signaling Primer Library |
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MCREB-I | Real Time Primers | 1 set | 657.6 EUR |
Mouse EGFR Signaling Primer Library |
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MEGFR-I | Real Time Primers | 1 set | 657.6 EUR |
TOR Signaling Pathway Detection Set |
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PSI-1805 | ProSci | 1 Set | 1287.6 EUR |
Description: The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle progression through its ability to integrate signals from nutrient levels and growth factors. TOR regulation is accomplished through a network of various activators and repressors. It is phosphorylated by Akt, whose activity is indirectly inhibited by the lipid phosphatase PTEN. TOR is normally associated with the regulatory proteins RAPTOR, a scaffold protein whose binding by TOR substrates is necessary for effective TOR-catalyzed phosphorylation, and GΒL, which stimulates TOR’s kinase activity towards downstream proteins. It is further regulated by the proteins Rheb, TSC1 and TSC2, which act to modulate TOR activity. The downstream targets of TOR are thought to be the ribosomal protein S6 kinases and the eukaryotic initiation factor 4E binding proteins (4EBPs) whose activation leads to increased protein translation and cell growth.;;For images please see PDF data sheet |
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Human EGFR Signaling Primer Library |
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HEGFR-I | Real Time Primers | 1 set | 657.6 EUR |
Human ERBB Signaling Primer Library |
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HERBB-I | Real Time Primers | 1 set | 657.6 EUR |
Human GDNF Signaling Primer Library |
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HGDNF-I | Real Time Primers | 1 set | 657.6 EUR |
Human IL17 Signaling Primer Library |
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HIL17-I | Real Time Primers | 1 set | 657.6 EUR |
Human BDNF Signaling Primer Library |
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HBDNF-I | Real Time Primers | 1 set | 657.6 EUR |
Human cAMP Signaling Primer Library |
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HCAMP-I | Real Time Primers | 1 set | 657.6 EUR |
Human CREB Signaling Primer Library |
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HCREB-I | Real Time Primers | 1 set | 657.6 EUR |
Human PDGF Signaling Primer Library |
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HPDGF-I | Real Time Primers | 1 set | 657.6 EUR |
Human SMAD Signaling Primer Library |
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HSMAD-I | Real Time Primers | 1 set | 657.6 EUR |
Human VEGF Signaling Primer Library |
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HVEGF-I | Real Time Primers | 1 set | 657.6 EUR |
Cyclopamine (Hedgehog signaling blocker) |
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SIH-226-1MG | Stressmarq | 1 mg | 162 EUR |
Description: The substance Cyclopamine is a hedgehog signaling blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 5 mM in ethanol. |
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Cyclopamine (Hedgehog signaling blocker) |
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SIH-226-5MG | Stressmarq | 5 mg | 414 EUR |
Description: The substance Cyclopamine is a hedgehog signaling blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 5 mM in ethanol. |
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Mouse Hippo Signaling Primer Library |
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MHPO-I | Real Time Primers | 1 set | 657.6 EUR |
Mouse Notch Signaling Primer Library |
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MNOT-I | Real Time Primers | 1 set | 657.6 EUR |
Human Hippo Signaling Primer Pathway |
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HHPO-I | Real Time Primers | 1 set | 657.6 EUR |
Rat Integrin Signaling Primer Library |
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RINT-I | Real Time Primers | 1 set | 1008 EUR |
Agouti Signaling Protein (ASIP) Antibody |
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abx122198-100ug | Abbexa | 100 ug | 469.2 EUR |
Agouti Signaling Protein (ASIP) Antibody |
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20-abx148376 | Abbexa |
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Agouti Signaling Protein (ASIP) Antibody |
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20-abx005235 | Abbexa |
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Mouse Hypoxia Signaling Primer Library |
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MHYP-I | Real Time Primers | 1 set | 657.6 EUR |
DiscoveryProbe? NF-?B Signaling Library |
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L1044-.1 | ApexBio | 100 uL/well(10 mM solution) | 1730.4 EUR |
DiscoveryProbe? NF-?B Signaling Library |
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L1044-.25 | ApexBio | 250 uL/well(10 mM solution) | 3052.8 EUR |
DiscoveryProbe? NF-?B Signaling Library |
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L1044-5 | ApexBio | 5 mg/well | 3970.8 EUR |
Human Hypoxia Signaling Primer Library |
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HHYP-I | Real Time Primers | 1 set | 657.6 EUR |
DiscoveryProbe? Neuronal Signaling Library |
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L1026-.1 | ApexBio | 100 uL/well(10 mM solution) | 5961.6 EUR |
DiscoveryProbe? Neuronal Signaling Library |
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L1026-.25 | ApexBio | 250 uL/well(10 mM solution) | 10639.2 EUR |
DiscoveryProbe? Neuronal Signaling Library |
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L1026-5 | ApexBio | 5 mg/well | 13840.8 EUR |
Mouse Integrin Signaling Primer Library |
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MINT-I | Real Time Primers | 1 set | 891.6 EUR |
Human Estrogen Signaling Primer Library |
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HESR-I | Real Time Primers | 1 set | 774 EUR |
Human Hedgehog Signaling Primer Library |
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HHOG-I | Real Time Primers | 1 set | 774 EUR |
Human Integrin Signaling Primer Library |
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HINT-I | Real Time Primers | 1 set | 657.6 EUR |
Human Androgen Signaling Primer Library |
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HAND-I | Real Time Primers | 1 set | 657.6 EUR |
Myc Reporter Kit (Myc Signaling Pathway) |
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60519 | BPS Bioscience | 500 rxns. | 625 EUR |
Description: The Myc Pathway Reporter kit is designed for monitoring the activity of the Myc signaling pathway in cultured cells. The kit contains a transfection-ready expression vector for c- Myc and Myc luciferase reporter vector. Inside the cells, c-Myc will bind to Max, translocate to the nucleus, and induce expression of the Myc luciferase reporter vector. This reporter contains the firefly luciferase gene under the control of multimerized Myc responsive elements located upstream of a minimal promoter. The Myc reporter is premixed with constitutively-expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutivelyexpressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway-specific effects and background luciferase activity. |
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Mouse TGF Beta Signaling Primer Library |
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MTGFB-I | Real Time Primers | 1 set | 657.6 EUR |