Description: Purified recombinant Human LBP protein

Description: Purified recombinant mouse LBP protein

Description: Rabbit polyclonal LBP antibody

Description: Affinity purified Rabbit polyclonal LBP antibody

Description: Rabbit polyclonal LBP antibody raised against the C terminal of LBP

Description: Rabbit polyclonal LBP antibody raised against the middle region of LBP

Description: A polyclonal antibody against LBP. Recognizes LBP from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/40000

Description: A polyclonal antibody against LBP. Recognizes LBP from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC

Description: A polyclonal antibody against LBP. Recognizes LBP from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Description: Antibody raised against LBP

Description: Antibody raised against LBP

Description: Antibody raised against LBP

Description: A cloning plasmid for the LBP gene.

Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LBP antibody, catalog no. 70R-5906

Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LBP antibody, catalog no. 70R-5907

Description: Lipopolysaccharide binding protein (LBP) is a plasma protein, belongs to a member of structurally and functionally related proteins which includes bactericidal permeability-increasing protein (BPI), plasma cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP). It is involved in the acute-phase immunologic response to gram-negative bacterial infections. In cooperation with BPI. LBP binds LPS and interacts with the CD14 receptor, most likely playing a role in regulating LPS-dependent monocyte responses. Studies suggest that LBP is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. Finally, t The LBP gene is found on chromosome 20, directly downstream of the BPI gene.

Description: A polyclonal antibody for detection of LBP from Human, Mouse, Rat. This LBP antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LBP at AA rangle: 190-270

Description: A polyclonal antibody for detection of LBP from Human, Mouse, Rat. This LBP antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LBP at AA rangle: 190-270

Description: A polyclonal antibody for detection of LBP from Human, Mouse, Rat. This LBP antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LBP at AA rangle: 190-270

Description: A Rabbit Polyclonal antibody against LBP from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Description: A Rabbit Polyclonal antibody against LBP from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of LBP in Rat serum, plasma and other biological fluids

Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of LBP in human serum, plasma and other biological fluids

Description: A polyclonal antibody against LBP. Recognizes LBP from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against LBP. Recognizes LBP from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against LBP. Recognizes LBP from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Description: Enzyme-linked immunosorbent assay kit for quantification of Human LBP in samples from serum, plasma, tissue homogenates and other biological fluids.

Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse LBP in samples from serum, plasma, tissue homogenates and other biological fluids.

Description: Description of target: ;Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.137 ng/mL

Description: Description of target: Plays a role in the innate immune response . Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria . Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide .;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.6 pg/mL

Description: Description of target: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: < 0.137ng/mL

Description: Description of target: Binds lipopolysaccharide on outer membrane of gram negative bacteria; involved in immune response ;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.42 ng/mL

Description: Description of target: ;Species reactivity: Pig;Application: ;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.67 ng/mL

Description: For quantitative detection of human LBP in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of mouse LBP in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: Description of target: Lipopolysaccharide binding protein is a protein that in humans is encoded by the LBP gene. This gene is mapped to 20q11.23. LBP is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (or LPS) to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4. It is present in the cerebrospinal fluid of patients with pneumococcal meningitis. The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. LBP is made in the liver during the acute phase of infections and is thought to function as a carrier for LPS and to help control LPS-dependent monocyte responses.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 50 pg/mL

Description: Description of target: Lipopolysaccharide binding protein is a protein that in humans is encoded by the LBP gene. This gene is mapped to 20q11.23. LBP is a soluble acute-phase protein that binds to bacterial lipopolysaccharide(or LPS) to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4. It is present in the cerebrospinal fluid of patients with pneumococcal meningitis. The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. LBP is made in the liver during the acute phase of infections and is thought to function as a carrier for LPS and to help control LPS-dependent monocyte responses.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <50pg/ml

Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.62 ng/mL

Description: Description of target: The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP).;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 1.29 ng/mL

Description: Description of target: Recombinant Mouse Lipopolysaccarid Binding Protein;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 0.62ng/mL

Description: Description of target: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).1 Publication <p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More…</a></p> Manual assertion inferred by curator fromiRef.11"Structural biology of the LPS recognition."_x005F_x005F_x000D_Jerala R._x005F_x005F_x000D_Int. J. Med. Microbiol. 297:353-363(2007) [PubMed] [Europe PMC] [Abstract]Cited for: REVIEW.4 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.2"Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation."_x005F_x005F_x000D_Wilde C.G., Seilhamer J.J., McGrogan M., Ashton N., Snable J.L., Lane J.C., Leong S.R., Thornton M.B., Miller K.L., Scott R.W._x005F_x005F_x000D_J. Biol. Chem. 269:17411-17416(1994) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.Ref.10"CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein."_x005F_x005F_x000D_Wright S.D., Ramos R.A., Tobias P.S., Ulevitch R.J., Mathison J.C._x005F_x005F_x000D_Science 249:1431-1433(1990) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH CD14 AND LIPOPOLYSACCHARIDE.Ref.13"Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells."_x005F_x005F_x000D_Tsukamoto H., Fukudome K., Takao S., Tsuneyoshi N., Kimoto M._x005F_x005F_x000D_Int. Immunol. 22:271-280(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.14"The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity."_x005F_x005F_x000D_Eckert J.K., Kim Y.J., Kim J.I., Guertler K., Oh D.Y., Sur S., Lundvall L., Hamann L., van der Ploeg A., Pickkers P., Giamarellos-Bourboulis E., Kubarenko A.V., Weber A.N., Kabesch M., Kumpf O., An H.J., Lee J.O., Schumann R.R._x005F_x005F_x000D_Immunity 39:647-660(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, 3D-STRUCTURE MODELING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, VARIANT LEU-333, CHARACTERIZATION OF VARIANT LEU-333. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 1.24 ng/mL

Description: Description of target: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.41 ng/mL

Description: Description of target: ;Species reactivity: Bovine;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.288 ng/mL

Description: Description of target: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.;Species reactivity: Bovine;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 3.9 ng/mL

Description: Description of target: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.;Species reactivity: Bovine;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.291 ng/mL

Description: Description of target: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.;Species reactivity: Bovine;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.281 ng/mL

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LBP - middle region. This antibody is tested and proven to work in the following applications: