We current proof that the sign recognition particle (SRP) acknowledges sign sequences through the NG area on the SRP54 protein subunit. Utilizing a just lately developed cross-linking methodology (Fancy, D. A., and Kodadek, T. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 6020-6024; Correction (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1317), we discover that sign peptides cross-link to the Escherichia coli SRP protein Ffh (the homologue of the mammalian SRP54 subunit) through the NG area.
Inside the NG area, the cross-linking web site maps to the ras-like C-terminal subdomain termed the G area. This consequence stands in distinction to earlier research, which concluded based mostly on nascent chain cross-linking that the sign sequence certain to the adjoining M area. As unbiased proof of a direct binding interplay between the NG area and the sign sequence, we discover that the NG area of Ffh binds sign peptides as an remoted entity. Our outcomes recommend that the NG area types a considerable a part of the binding web site for the sign sequence.

p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Built-in Pulsed Secure Isotope Labeling With Amino Acids in Cell Tradition (pSILAC) and Subsequent Era Sequencing (NGS) Analyses.

We decided the impact of p53 activation on de novo protein synthesis utilizing quantitative proteomics (pulsed secure isotope labeling with amino acids in cell tradition/pSILAC) within the colorectal most cancers cell line SW480. This was mixed with mRNA and noncoding RNA expression analyses by subsequent technology sequencing (RNA-, miR-Seq). Moreover, genome-wide DNA binding of p53 was analyzed by chromatin-immunoprecipitation (ChIP-Seq).
Thereby, we recognized differentially regulated proteins (542 up, 569 down), mRNAs (1258 up, 415 down), miRNAs (111 up, 95 down) and lncRNAs (270 up, 123 down). Modifications in protein and mRNA expression ranges confirmed a constructive correlation (r = 0.50, p < 0.0001). In whole, we detected 133 direct p53 goal genes that had been differentially expressed and displayed p53 occupancy within the neighborhood of their promoter.
Extra transcriptionally induced genes displayed occupied p53 binding websites (4.3% mRNAs, 7.2% miRNAs, 6.3% lncRNAs, 5.9% proteins) than repressed genes (2.4% mRNAs, 3.2% miRNAs, 0.8% lncRNAs, 1.9% proteins), suggesting oblique mechanisms of repression. Round 50% of the down-regulated proteins displayed seed-matching sequences of p53-induced miRNAs within the corresponding 3′-UTRs.
Furthermore, proteins repressed by p53 considerably overlapped with these beforehand proven to be repressed by miR-34a. We confirmed up-regulation of the novel direct p53 goal genes LINC01021, MDFI, ST14 and miR-486 and confirmed that ectopic LINC01021 expression inhibits proliferation in SW480 cells. Moreover, KLF12, HMGB1 and CIT mRNAs had been confirmed as direct targets of the p53-induced miR-34a, miR-205 and miR-486-5p, respectively.
Mapping the signal sequence-binding site on SRP reveals a significant role for the NG domain.
According to the lack of p53 operate throughout tumor development, elevated expression of KLF12, HMGB1 and CIT was detected in superior phases of most cancers. In conclusion, the combination of a number of omics strategies allowed the excellent identification of direct and oblique effectors of p53 that present new insights and leads into the mechanisms of p53-mediated tumor suppression.

Subsequent-generation sequencing (NGS) for evaluation of microbial water high quality: present progress, challenges, and future alternatives.

Water high quality is an emergent property of a posh system comprised of interacting microbial populations and launched microbial and chemical contaminants. Research leveraging next-generation sequencing (NGS) applied sciences are offering new insights into the ecology of microbially mediated processes that affect contemporary water high quality reminiscent of algal blooms, contaminant biodegradation, and pathogen dissemination. As well as, sequencing strategies focusing on small subunit (SSU) rRNA hypervariable areas have allowed identification of signature microbial species that function bioindicators for sewage contamination in these environments.
Past amplicon sequencing, metagenomic and metatranscriptomic analyses of microbial communities in contemporary water environments reveal the genetic capabilities and interaction of waterborne microorganisms, shedding gentle on the mechanisms for manufacturing and biodegradation of poisons and different contaminants. This evaluate discusses the challenges and advantages of making use of NGS-based strategies to water high quality analysis and evaluation.
We’ll contemplate the suitability and biases inherent within the software of NGS as a screening software for evaluation of organic dangers and talk about the potential and limitations for direct quantitative interpretation of NGS knowledge.
Secondly, we’ll study case research from latest literature the place NGS based mostly strategies have been utilized to matters in water high quality evaluation, together with growth of bioindicators for sewage air pollution and microbial supply monitoring, characterizing the distribution of toxin and antibiotic resistance genes in water samples, and investigating mechanisms of biodegradation of dangerous pollution that threaten water high quality. Lastly, we offer a brief evaluate of rising NGS platforms and their potential purposes to the subsequent technology of water high quality evaluation instruments.

Inference of Markovian properties of molecular sequences from NGS knowledge and purposes to comparative genomics.

Subsequent-generation sequencing (NGS) applied sciences generate massive quantities of quick learn knowledge for a lot of totally different organisms. The truth that NGS reads are typically quick makes it difficult to assemble the reads and reconstruct the unique genome sequence. For clustering genomes utilizing such NGS knowledge, word-count based mostly alignment-free sequence comparability is a promising method, however for this method, the underlying anticipated phrase counts are important

Mouse Androgen Receptor (AR) ELISA Kit
RD-AR-Mu-48Tests 48 Tests
EUR 511

Mouse Androgen Receptor (AR) ELISA Kit
RD-AR-Mu-96Tests 96 Tests
EUR 709

Rat Androgen Receptor (AR) ELISA Kit
RD-AR-Ra-48Tests 48 Tests
EUR 534

Rat Androgen Receptor (AR) ELISA Kit
RD-AR-Ra-96Tests 96 Tests
EUR 742

Human Androgen Receptor (AR) ELISA Kit
RDR-AR-Hu-48Tests 48 Tests
EUR 522

Human Androgen Receptor (AR) ELISA Kit
RDR-AR-Hu-96Tests 96 Tests
EUR 724

Mouse Androgen Receptor (AR) ELISA Kit
RDR-AR-Mu-48Tests 48 Tests
EUR 534

Mouse Androgen Receptor (AR) ELISA Kit
RDR-AR-Mu-96Tests 96 Tests
EUR 742

Rat Androgen Receptor (AR) ELISA Kit
RDR-AR-Ra-48Tests 48 Tests
EUR 558

Rat Androgen Receptor (AR) ELISA Kit
RDR-AR-Ra-96Tests 96 Tests
EUR 776

Ar/ Rat Ar ELISA Kit
ELI-04146r 96 Tests
EUR 886

AR-08
HY-U00371 20mg
EUR 13439

AR-A014418
HY-10512 50mg
EUR 342

AR-9281
HY-111151 5mg
EUR 211

AR-C155858
HY-13248 10mM/1mL
EUR 483

AR 231453
HY-15564 10mM/1mL
EUR 160

AR A014418
20-abx076761
  • EUR 718.00
  • EUR 314.00
  • 25 mg
  • 5 mg

AR Antibody
32572-100ul 100ul
EUR 252

AR-A014418
A3184-10 10 mg
EUR 128
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor.

AR-A014418
A3184-5.1 10 mM (in 1mL DMSO)
EUR 123
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor.

AR-A014418
A3184-50 50 mg
EUR 268
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor.

AR-A014418
A3184-S Evaluation Sample
EUR 81
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor.

AR-C155858
A3185-10 10 mg
EUR 991
Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members.

AR-C155858
A3185-5 5 mg
EUR 611
Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members.

AR-C155858
A3185-50 50 mg
EUR 2800
Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members.

AR siRNA
20-abx900461
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

AR siRNA
20-abx908237
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

AR siRNA
20-abx908238
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

AR 231453
B3269-10 10 mg
EUR 245
Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors.

AR 231453
B3269-5 5 mg
EUR 179
Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors.

AR 231453
B3269-5.1 10 mM (in 1mL DMSO)
EUR 195
Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors.

AR Antibody
1-CSB-PA056943
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:25-1:100

AR Antibody
1-CSB-PA05979A0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

AR Antibody
1-CSB-PA011255
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000

AR Antibody
1-CSB-PA011256
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000

AR Antibody
1-CSB-PA011257
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000

AR Antibody
1-CSB-PA011258
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

AR Antibody
CSB-PA001975KA01HU-
EUR 335
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, ICC;WB:1:500-1:1000, IHC:1:50-1:100, ICC:1:50-1:100

AR Antibody
CSB-PA001975KA01HU-100ul 100ul
EUR 389
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, ICC;WB:1:500-1:1000, IHC:1:50-1:100, ICC:1:50-1:100

AR Antibody
1-CSB-PA006094
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

AR Antibody
BF0418 200ul
EUR 376
Description: AR antibody detects endogenous levels of total AR.

AR Antibody
DF6783 200ul
EUR 304
Description: AR Antibody detects endogenous levels of total AR.

AR Antibody
ABD6783 100 ug
EUR 438

AR-C155858
B2743-1 1 mg
EUR 348

Clematichinenoside AR
TBW00371 10mg
EUR 847

ar-Tumerone
TBW01373 5mg Ask for price

pCDNA3.1-AR
PVT18102 2 ug
EUR 300

AR antibody
10R-2031 100 ul
EUR 403
Description: Mouse monoclonal AR antibody

AR antibody
70R-35838 100 ug
EUR 327
Description: Rabbit polyclonal AR antibody

KAF/AR/ Rat KAF/ AR ELISA Kit
ELA-E0006r 96 Tests
EUR 886

AR Polyclonal Antibody
ES5938-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

AR Polyclonal Antibody
ES5938-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

AR Polyclonal Antibody
ES5939-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for IHC, WB, ELISA

AR Polyclonal Antibody
ES5939-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for IHC, WB, ELISA

AR Polyclonal Antibody
ES5940-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse. This antibody is tested and validated for IHC, IF, WB, ELISA

AR Polyclonal Antibody
ES5940-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse. This antibody is tested and validated for IHC, IF, WB, ELISA

AR Polyclonal Antibody
ES5941-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

AR Polyclonal Antibody
ES5941-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

AR-42J cells
C0018004 One Frozen vial
EUR 455

AR-C102222 (hydrochloride)
HY-12122A 10mg
EUR 1175

AR Polyclonal Antibody
ES4268-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

AR Polyclonal Antibody
ES4268-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

AR Polyclonal Antibody
ABP54939-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S650

AR Polyclonal Antibody
ABP54939-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S650

AR Polyclonal Antibody
ABP54939-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S650

AR Polyclonal Antibody
ABP54940-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S213

AR Polyclonal Antibody
ABP54940-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S213

AR Polyclonal Antibody
ABP54940-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S213

AR Polyclonal Antibody
ABP54941-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of AR from Human, Mouse. This AR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S94

AR Polyclonal Antibody
ABP54941-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of AR from Human, Mouse. This AR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S94

AR Polyclonal Antibody
ABP54941-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of AR from Human, Mouse. This AR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S94

AR Polyclonal Antibody
ABP54942-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of Y363

AR Polyclonal Antibody
ABP54942-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of Y363

AR Polyclonal Antibody
ABP54942-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of Y363

AR Polyclonal Antibody
ABP53269-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AR

AR Polyclonal Antibody
ABP53269-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AR

AR Polyclonal Antibody
ABP53269-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AR

AR (pS213) Antibody
20-abx000354
  • EUR 495.00
  • EUR 704.00
  • EUR 356.00
  • 100 ul
  • 200 ul
  • 50 ul

AR (pS650) Antibody
20-abx000355
  • EUR 495.00
  • EUR 704.00
  • EUR 356.00
  • 100 ul
  • 200 ul
  • 50 ul

Anti-AR antibody
STJ91659 200 µl
EUR 197
Description: Rabbit polyclonal to AR.

Anti-AR antibody
STJ91660 200 µl
EUR 197
Description: Rabbit polyclonal to AR.

Anti-AR antibody
STJ91661 200 µl
EUR 197
Description: Rabbit polyclonal to AR.

Anti-AR antibody
STJ91662 200 µl
EUR 197
Description: Rabbit polyclonal to AR.

Anti-AR antibody
STJ97233 200 µl
EUR 197
Description: AR is a protein encoded by the AR gene which is approximately 99,1 kDa. AR is localised to the nucleus and cytoplasm. It is involved in deubiquitination, gene expression, metabolism of proteins and the nuclear receptor transcription pathway. It functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. AR is expressed in the liver, nervous system, blood, muscle and kidney. Mutations in the AR gene may result in prostate cancer. STJ97233 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of AR protein.

Anti-AR antibody
STJ97845 100 µl
EUR 234
Description: Mouse monoclonal to AR.

Anti-AR antibody
STJ97846 100 µl
EUR 234
Description: Mouse monoclonal to AR.

Anti-AR Antibody
STJ193178 200 µl
EUR 197

Anti-AR antibody
STJ22662 100 µl
EUR 277
Description: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

AR ELISA Kit
STJ150094 1 kit
EUR 412
Description: The kit is a competitive enzyme immunoassay for in vitro quantitative measurement of T in serum, plasma and other biological fluids

AR Polyclonal Antibody
40609-100ul 100ul
EUR 252

AR Polyclonal Antibody
40609-50ul 50ul
EUR 187

AR Polyclonal Antibody
40610-100ul 100ul
EUR 252
.A believable mannequin for this underlying distribution of phrase counts is given by means of modeling the DNA sequence as a Markov chain (MC). For single lengthy sequences, environment friendly statistics can be found to estimate the order of MCs and the transition chance matrix for the sequences. As NGS knowledge don’t present a single lengthy sequence, inference strategies on Markovian properties of sequences based mostly on single lengthy sequences can’t be instantly used for NGS quick learn knowledge.