Mapping the signal sequence-binding site on SRP reveals a significant role for the NG domain.

We current proof that the sign recognition particle (SRP) acknowledges sign sequences through the NG area on the SRP54 protein subunit. Utilizing a just lately developed cross-linking methodology (Fancy, D. A., and Kodadek, T. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 6020-6024; Correction (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1317), we discover that sign peptides cross-link to the Escherichia coli SRP protein Ffh (the homologue of the mammalian SRP54 subunit) through the NG area.
Inside the NG area, the cross-linking web site maps to the ras-like C-terminal subdomain termed the G area. This consequence stands in distinction to earlier research, which concluded based mostly on nascent chain cross-linking that the sign sequence certain to the adjoining M area. As unbiased proof of a direct binding interplay between the NG area and the sign sequence, we discover that the NG area of Ffh binds sign peptides as an remoted entity. Our outcomes recommend that the NG area types a considerable a part of the binding web site for the sign sequence.
p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Built-in Pulsed Secure Isotope Labeling With Amino Acids in Cell Tradition (pSILAC) and Subsequent Era Sequencing (NGS) Analyses.
We decided the impact of p53 activation on de novo protein synthesis utilizing quantitative proteomics (pulsed secure isotope labeling with amino acids in cell tradition/pSILAC) within the colorectal most cancers cell line SW480. This was mixed with mRNA and noncoding RNA expression analyses by subsequent technology sequencing (RNA-, miR-Seq). Moreover, genome-wide DNA binding of p53 was analyzed by chromatin-immunoprecipitation (ChIP-Seq).
Thereby, we recognized differentially regulated proteins (542 up, 569 down), mRNAs (1258 up, 415 down), miRNAs (111 up, 95 down) and lncRNAs (270 up, 123 down). Modifications in protein and mRNA expression ranges confirmed a constructive correlation (r = 0.50, p < 0.0001). In whole, we detected 133 direct p53 goal genes that had been differentially expressed and displayed p53 occupancy within the neighborhood of their promoter.
Extra transcriptionally induced genes displayed occupied p53 binding websites (4.3% mRNAs, 7.2% miRNAs, 6.3% lncRNAs, 5.9% proteins) than repressed genes (2.4% mRNAs, 3.2% miRNAs, 0.8% lncRNAs, 1.9% proteins), suggesting oblique mechanisms of repression. Round 50% of the down-regulated proteins displayed seed-matching sequences of p53-induced miRNAs within the corresponding 3′-UTRs.
Furthermore, proteins repressed by p53 considerably overlapped with these beforehand proven to be repressed by miR-34a. We confirmed up-regulation of the novel direct p53 goal genes LINC01021, MDFI, ST14 and miR-486 and confirmed that ectopic LINC01021 expression inhibits proliferation in SW480 cells. Moreover, KLF12, HMGB1 and CIT mRNAs had been confirmed as direct targets of the p53-induced miR-34a, miR-205 and miR-486-5p, respectively.

According to the lack of p53 operate throughout tumor development, elevated expression of KLF12, HMGB1 and CIT was detected in superior phases of most cancers. In conclusion, the combination of a number of omics strategies allowed the excellent identification of direct and oblique effectors of p53 that present new insights and leads into the mechanisms of p53-mediated tumor suppression.
Subsequent-generation sequencing (NGS) for evaluation of microbial water high quality: present progress, challenges, and future alternatives.
Water high quality is an emergent property of a posh system comprised of interacting microbial populations and launched microbial and chemical contaminants. Research leveraging next-generation sequencing (NGS) applied sciences are offering new insights into the ecology of microbially mediated processes that affect contemporary water high quality reminiscent of algal blooms, contaminant biodegradation, and pathogen dissemination. As well as, sequencing strategies focusing on small subunit (SSU) rRNA hypervariable areas have allowed identification of signature microbial species that function bioindicators for sewage contamination in these environments.
Past amplicon sequencing, metagenomic and metatranscriptomic analyses of microbial communities in contemporary water environments reveal the genetic capabilities and interaction of waterborne microorganisms, shedding gentle on the mechanisms for manufacturing and biodegradation of poisons and different contaminants. This evaluate discusses the challenges and advantages of making use of NGS-based strategies to water high quality analysis and evaluation.
We’ll contemplate the suitability and biases inherent within the software of NGS as a screening software for evaluation of organic dangers and talk about the potential and limitations for direct quantitative interpretation of NGS knowledge.
Secondly, we’ll study case research from latest literature the place NGS based mostly strategies have been utilized to matters in water high quality evaluation, together with growth of bioindicators for sewage air pollution and microbial supply monitoring, characterizing the distribution of toxin and antibiotic resistance genes in water samples, and investigating mechanisms of biodegradation of dangerous pollution that threaten water high quality. Lastly, we offer a brief evaluate of rising NGS platforms and their potential purposes to the subsequent technology of water high quality evaluation instruments.
Inference of Markovian properties of molecular sequences from NGS knowledge and purposes to comparative genomics.
Subsequent-generation sequencing (NGS) applied sciences generate massive quantities of quick learn knowledge for a lot of totally different organisms. The truth that NGS reads are typically quick makes it difficult to assemble the reads and reconstruct the unique genome sequence. For clustering genomes utilizing such NGS knowledge, word-count based mostly alignment-free sequence comparability is a promising method, however for this method, the underlying anticipated phrase counts are important
Beckman Tungsten Lamp |
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LT-BEC-100 | Scientific Laboratory Supplies | EACH | 58.8 EUR |
Jasco V500. 50 Tungsten Lamp |
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LT-JAS-102 | Scientific Laboratory Supplies | EACH | 58.8 EUR |
ICP Std Tungsten 1000ug/mL in 2% NH4OH |
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PW2A7 | Scientific Laboratory Supplies | 100ML | 221.95 EUR |
ICP Std Tungsten 1000ug/mL in 2% NH4OH |
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PW2B7 | Scientific Laboratory Supplies | 250ML | 359.04 EUR |
ICP Std Tungsten 1000ug/mL in 2% NH4OH |
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PW2C7 | Scientific Laboratory Supplies | 500ML | 489.6 EUR |
ICP Std Tungsten 10000ug/mL in 2% NH4OH |
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PW4A7 | Scientific Laboratory Supplies | 100ML | 386.46 EUR |
ICP Std Tungsten 10000ug/mL in 2% NH4OH |
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PW4B7 | Scientific Laboratory Supplies | 250ML | 462.18 EUR |
Kinesis TSP uV100/1000/2000/3000 Tungsten Lamp |
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CHR6115 | Scientific Laboratory Supplies | EACH | 716.4 EUR |
Dionex Ultimate 3000 Tungsten Lamp |
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LT-DIO-105 | Scientific Laboratory Supplies | EACH | 387.6 EUR |
SKINNER LIST ACID EXTRACTABLES 1mL |
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SKINNER-AE | Scientific Laboratory Supplies | 1ML | 183.6 EUR |
Unicam 5625 5675 8600 8700 8800 Series Tungsten Lamp |
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LT-PHU-102 | Scientific Laboratory Supplies | EACH | 177.6 EUR |
Lamp Shimadzu Spec. Tungsten |
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IZ06265005AT | Scientific Laboratory Supplies | EACH | 49.74 EUR |
Kinesis TSP uV6000 Tungsten Lamp |
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CHR6116 | Scientific Laboratory Supplies | EACH | 385.2 EUR |
Shimadzu M10AVP Tungsten Lamp |
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LT-SHI-104 | Scientific Laboratory Supplies | EACH | 57.6 EUR |
Sodium tungstate dihydrate |
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GK6152-100G | Glentham Life Sciences | 100 g | 79.2 EUR |
Sodium tungstate dihydrate |
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GK6152-250G | Glentham Life Sciences | 250 g | 122.4 EUR |
Sodium tungstate dihydrate |
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GK6152-25G | Glentham Life Sciences | 25 g | 56.4 EUR |
Sodium tungstate dihydrate |
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GK6152-500G | Glentham Life Sciences | 500 g | 189.6 EUR |
Sodium tungstate, dihydrate |
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S0898 | Bio Basic | 250g | 130.99 EUR |
Cecil Series 2. 1000 to 9000. CE Sereis Tungsten Lamp |
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LT-CEC-111 | Scientific Laboratory Supplies | EACH | 106.8 EUR |
Viral Nucleic Acid Extraction KitDNA/RNA |
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FYG401-100P | Yeastern Biotech | 100 Preps | Ask for price |
Viral Nucleic Acid Extraction KitDNA/RNA |
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FYG401-300P | Yeastern Biotech | 300 Preps | Ask for price |
Viral Nucleic Acid Extraction KitDNA/RNA |
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FYG401-50P | Yeastern Biotech | 50 Preps | Ask for price |
Assurance Grade Tungsten for AA and ICP 1000 ug/mL (1000 PPM) 30mL in H2O |
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PLW9-2M | Scientific Laboratory Supplies | 30ML | 34.8 EUR |
Assurance Grade Tungsten for AA and ICP 1000 ug/mL (1000 PPM) 500mL in H2O |
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PLW9-2X | Scientific Laboratory Supplies | 500ML | 150 EUR |
Assurance Grade Tungsten for AA and ICP 1000 ug/mL (1000 PPM) 125mL in H2O |
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PLW9-2Y011 | Scientific Laboratory Supplies | 125ML | 66 EUR |
Assurance Grade Tungsten for AA and ICP 10000 ug/mL (10000 PPM) 500mL in H2O |
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PLW9-3X | Scientific Laboratory Supplies | 500ML | 273.6 EUR |
Assurance Grade Tungsten for AA and ICP 10000 ug/mL (10000 PPM) 125mL in H2O |
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PLW9-3Y | Scientific Laboratory Supplies | 125ML | 116.4 EUR |
Shimadzu SPD-10AV. AVP. AVVP. 20AV Tungsten Lamp |
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LT-SHI-101 | Scientific Laboratory Supplies | EACH | 273.6 EUR |
Assurance Grade Tungsten for AA and ICP 1000 ug/mL (1000 PPM) 500mL in 1% HNO3 / 2% HF |
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PLW2-2X | Scientific Laboratory Supplies | 500ML | 158.4 EUR |
Assurance Grade Tungsten for AA and ICP 10000 ug/mL (10000 PPM) 500mL in 2% HNO3 / 5% HF |
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PLW2-3X | Scientific Laboratory Supplies | 500ML | 272.4 EUR |
Viral Nucleic Acid Extraction Kit II (50prep) |
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FAVNK-002 | Favorgen | 50 preps | 198 EUR |
Viral Nucleic Acid Extraction Kit II (100prep) |
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FAVNK-002-1 | Favorgen | 100 preps | 259.2 EUR |
Viral Nucleic Acid Extraction Kit II (300prep) |
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FAVNK-002-2 | Favorgen | 300 preps | 476.4 EUR |
Kinesis Hollow Cathode Lamp Tungsten 37mm Std |
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CHR6070 | Scientific Laboratory Supplies | EACH | 334.23 EUR |
Claritas PPT Grade Tungsten for ICP-MS 1 ug/mL (1 PPM) 125mL in 2% HNO3 / tr HF |
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CLW2-1BY | Scientific Laboratory Supplies | 125ML | 117.6 EUR |
vamPure™ Blood Nucleic Acid Extraction Kit |
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K5011720 | Biochain | 1 kit | 245 EUR |
Kinesis Hollow Cathode Lamp Tungsten 37mm unicam |
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CHR6071 | Scientific Laboratory Supplies | EACH | 385.15 EUR |
Kinesis Hollow Cathode Lamp Tungsten 37mm Varian |
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CHR6072 | Scientific Laboratory Supplies | EACH | 385.15 EUR |
Two (2) GAGG Sentinel Beamstop with Tungsten Housing |
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DBS-GAGGBS-2-B | MiTeGen | 2 UNITS | 5358 EUR |
Description: Two (2) GAGG Sentinel Beamstop with Tungsten Housing |
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TCLP Base/Neutral/Acid Extractable Spike Solution |
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TCLP-BNA | Scientific Laboratory Supplies | 1ML | 80.4 EUR |
TCLP Base/Neutral/Acid Extractable Spike Solution |
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TCLP-BNA-5 | Scientific Laboratory Supplies | 5ML | 386.4 EUR |
LKB Pharmacia Ultrospec 2000 3000 Novaspec ii Tungsten Lamp |
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LT-LKB-100 | Scientific Laboratory Supplies | EACH | 49.2 EUR |
Unicam UV1 Helios Alpha. Beta Gamma and Delta Tungsten Lamp |
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LT-PHU-103 | Scientific Laboratory Supplies | EACH | 136.8 EUR |
Kinesis Hollow Cathode Lamp Tungsten 50mm Standard |
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CHR6073 | Scientific Laboratory Supplies | EACH | 488.29 EUR |
Acid Extractables Surrogate Mix (3) (2000ppm) - 5.5mL Bottle |
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ECS-N-003 | Scientific Laboratory Supplies | 5.5ML | 61.2 EUR |
Acid Extractables Surrogate Mix (4) (2000ppm) - 5.5mL Bottle |
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ECS-N-023 | Scientific Laboratory Supplies | 5.5ML | 115.2 EUR |
Acid Extractables Surrogate Mix (3) (2000ppm) - 11.5mL Bottle |
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ECS-Z-003 | Scientific Laboratory Supplies | 11.5ML | 114 EUR |
JBS Tungstate Cluster Kit; contains 3 different clusters |
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M-PK-108 | MiTeGen | 10.5 mg | 178 EUR |
Description: JBS Tungstate Cluster Kit; contains 3 different clusters |
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Kinesis Hollow Cathode Lamp Tungsten 50mm PE AAnalyst (Lumina) |
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CHR6074 | Scientific Laboratory Supplies | EACH | 617.55 EUR |
Acid Extractables Surrogate Mix 4 component-10.5mL Bottle |
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ECS-Z-023 | Scientific Laboratory Supplies | 10.5ML | 213.6 EUR |
IKA M 22 hard tungsten carbide cutter for materials upto Mohs hardness 8 |
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MIL2132 | Scientific Laboratory Supplies | EACH | 534 EUR |
xTractPure™ Cell and Tissue Nucleic Acid Extraction Kit |
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Z2212005 | Biochain | 1 kit (96 extractions) | 449 EUR |
AnaPrep Viral Nucleic Acid Extraction Kit (48) For extracting viral nucleic acids from plasma |
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Z1322003 | Biochain | 1 kit (48 extractions) Including all required plastic disposables | 216 EUR |
EpiQuik Nuclear Extraction Kit II (Nucleic Acid-Free) |
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OP-0022 | EpiGentek |
|
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Xpert Nuclear Protein Extraction Kit, Nucleic acid free |
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N2200-050 | GenDepot | 50 ext | Ask for price |
Xpert Nuclear Protein Extraction Kit, Nucleic acid free |
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N2200-100 | GenDepot | 100 ext | Ask for price |
AnaPrep Viral Nucleic Acid Large Volume Extraction Kit |
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Z1322016 | Biochain | 1 kit (48 extractions) Including all required plastic disposables | 419 EUR |
Viral Nucleic Acid Extraction Kit (Proteinase K & Carrier RNA included) |
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RD05 | GeneOn | 5 preps | Ask for price |
Viral Nucleic Acid Extraction Kit (Proteinase K & Carrier RNA included) |
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RD25 | GeneOn | 25 preps | 120 EUR |
Viral Nucleic Acid Extraction Kit (Proteinase K & Carrier RNA included) |
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RD50 | GeneOn | 50 preps | 165.6 EUR |
GAGG Sentinel Beam Stops - Generation 2 with Tungsten Housing and GAGG Scintillator - Qty 1 |
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DBS-GAGGBS-1-B | MiTeGen | 1 UNIT | 2785 EUR |
Description: GAGG Sentinel Beam Stops - Generation 2 with Tungsten Housing and GAGG Scintillator - Qty 1 |
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Polyclonal Excitatory Amino Acid Transporter 1 (extracellular) Antibody |
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APR11871G | Leading Biology | 0.05ml | 790.8 EUR |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Excitatory Amino Acid Transporter 1 (extracellular) . This antibody is tested and proven to work in the following applications: |
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Viral Nucleic Acid Extraction Kit I (50prep), (With Carrier RNA, for low viral load specimen using carrier RNA) |
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FAVNK-001 | Favorgen | 50 preps | 198 EUR |
Viral Nucleic Acid Extraction Kit I (100prep), (With Carrier RNA, for low viral load specimen using carrier RNA) |
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FAVNK-001-1 | Favorgen | 100 preps | 259.2 EUR |
Viral Nucleic Acid Extraction Kit I (300prep), (With Carrier RNA, for low viral load specimen using carrier RNA) |
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FAVNK-001-2 | Favorgen | 300 preps | 476.4 EUR |
Okadaic acid, free acid |
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OL1198 | Bio Basic | 50ug | 231.22 EUR |
Fumalic acid(Ferulic acid) |
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E1KS2300 | EnoGene | 50mg | 390 EUR |
Octanoic acid (Caorylic acid) |
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O5678 | Bio Basic | 250ml | 80.88 EUR |
DL-Maleic acid (Toxilic acid) |
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MA0333 | Bio Basic | 250g | 77.4 EUR |
D-Glucuronic acid, free acid |
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GB0482 | Bio Basic | 5g | 186.19 EUR |
Ar/ Rat Ar ELISA Kit |
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ELI-04146r | Lifescience Market | 96 Tests | 1063.2 EUR |
MUCOBROMIC ACID (2,3‐ DIBROMOMALEALDEHYDIC ACID) |
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613004 | Survival Technologies | each | Ask for price |
AnaPrep Viral/Pathogen Nucleic Acids Extraction Kit A |
|||
Z1322011 | Biochain | 1 kit (48 extractions) Including all required plastic disposables | 216 EUR |
AnaPrep Viral/Pathogen Nucleic Acids Extraction Kit B |
|||
Z1322012 | Biochain | 1 kit (48 extractions) Including all required plastic disposables | 246 EUR |
Tide Quencher™ 1 acid [TQ1 acid] |
|||
2190 | AAT Bioquest | 100 mg | 222 EUR |
Tide Quencher™ 2 acid [TQ2 acid] |
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2200 | AAT Bioquest | 100 mg | 222 EUR |
Tide Quencher™ 3 acid [TQ3 acid] |
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2220 | AAT Bioquest | 100 mg | 222 EUR |
Rat Uric Acid(Uric Acid) ELISA Kit |
|||
YLA1447RA-48T | Shanghai YL Biotech | 48T | 465 EUR |
Rat Uric Acid(Uric Acid) ELISA Kit |
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YLA1447RA-96T | Shanghai YL Biotech | 96T | 600 EUR |
Human Uric Acid(Uric Acid) ELISA Kit |
|||
QY-E05411 | Qayee Biotechnology | 96T | 433.2 EUR |
Human Uric Acid(Uric Acid) ELISA Kit |
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YLA3946HU-48T | Shanghai YL Biotech | 48T | 435 EUR |
Human Uric Acid(Uric Acid) ELISA Kit |
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YLA3946HU-96T | Shanghai YL Biotech | 96T | 562.5 EUR |
ICG acid |
|||
189 | AAT Bioquest | 5 mg | 222 EUR |
Tide Quencher™ 3WS acid [TQ3WS acid] |
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2227 | AAT Bioquest | 5 mg | 222 EUR |
Tide Quencher™ 2WS acid [TQ2WS acid] |
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2050 | AAT Bioquest | 25 mg | 222 EUR |
Tide Quencher™ 4WS acid [TQ4WS acid] |
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2060 | AAT Bioquest | 5 mg | 222 EUR |
Tide Quencher™ 5WS acid [TQ5WS acid] |
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2075 | AAT Bioquest | 5 mg | 222 EUR |
Tide Quencher™ 6WS acid [TQ6WS acid] |
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2090 | AAT Bioquest | 5 mg | 334 EUR |
Tide Quencher™ 7WS acid [TQ7WS acid] |
|||
2105 | AAT Bioquest | 5 mg | 558 EUR |
Bovine Uric Acid (Uric Acid) ELISA Kit |
|||
YLA0364BO-48T | Shanghai YL Biotech | 48T | 502.5 EUR |
Bovine Uric Acid (Uric Acid) ELISA Kit |
|||
YLA0364BO-96T | Shanghai YL Biotech | 96T | 618.75 EUR |
Canine Uric Acid(Uric Acid) ELISA Kit |
|||
YLA0205CA-48T | Shanghai YL Biotech | 48T | 502.5 EUR |
Canine Uric Acid(Uric Acid) ELISA Kit |
|||
YLA0205CA-96T | Shanghai YL Biotech | 96T | 618.75 EUR |
Human D-lactic acid(D-lactic acid) |
|||
QY-E05453 | Qayee Biotechnology | 96T | 433.2 EUR |
Rat Lactic acid(lactic acid)ELISA Kit |
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YLA1391RA-48T | Shanghai YL Biotech | 48T | 465 EUR |
Rat Lactic acid(lactic acid)ELISA Kit |
|||
YLA1391RA-96T | Shanghai YL Biotech | 96T | 600 EUR |
Uric acid |
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HY-B2130 | MedChemExpress | 500mg | 129.6 EUR |
Uric acid |
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UB0978 | Bio Basic | 10g | 79.84 EUR |
AR antibody |
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10R-2031 | Fitzgerald | 100 ul | 483.6 EUR |
Description: Mouse monoclonal AR antibody |
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AR antibody |
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70R-35838 | Fitzgerald | 100 ug | 392.4 EUR |
Description: Rabbit polyclonal AR antibody |
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AR-A014418 |
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A3184-10 | ApexBio | 10 mg | 153.6 EUR |
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor. |
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AR-A014418 |
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A3184-5.1 | ApexBio | 10 mM (in 1mL DMSO) | 147.6 EUR |
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor. |
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AR-A014418 |
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A3184-50 | ApexBio | 50 mg | 321.6 EUR |
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor. |
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AR-A014418 |
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A3184-S | ApexBio | Evaluation Sample | 97.2 EUR |
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor. |
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AR-C155858 |
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A3185-10 | ApexBio | 10 mg | 1189.2 EUR |
Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members. |
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AR-C155858 |
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A3185-5 | ApexBio | 5 mg | 733.2 EUR |
Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members. |
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AR-C155858 |
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A3185-50 | ApexBio | 50 mg | 3360 EUR |
Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members. |
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AR Antibody |
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ABD6783 | Lifescience Market | 100 ug | 525.6 EUR |
AR Antibody |
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32572-100ul | SAB | 100ul | 302.4 EUR |
AR A014418 |
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20-abx076761 | Abbexa |
|
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AR Antibody |
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AF6137 | Affbiotech | 200ul | 420 EUR |
AR Antibody |
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AF6927 | Affbiotech | 100ul | 420 EUR |
AR-C155858 |
|||
B2743-1 | Biovision | 1 mg | 417.6 EUR |
AR 231453 |
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B3269-10 | ApexBio | 10 mg | 294 EUR |
Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors. |
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AR 231453 |
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B3269-5 | ApexBio | 5 mg | 214.8 EUR |
Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors. |
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AR 231453 |
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B3269-5.1 | ApexBio | 10 mM (in 1mL DMSO) | 234 EUR |
Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors. |
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AR Antibody |
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BF0349 | Affbiotech | 200ul | 540 EUR |
AR Antibody |
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BF0418 | Affbiotech | 200ul | 540 EUR |
AR Antibody |
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CSB-PA001975KA01HU- | Cusabio | each | 402 EUR |
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, ICC;WB:1:500-1:1000, IHC:1:50-1:100, ICC:1:50-1:100 |
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AR Antibody |
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CSB-PA001975KA01HU-100ul | Cusabio | 100ul | 466.8 EUR |
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, ICC;WB:1:500-1:1000, IHC:1:50-1:100, ICC:1:50-1:100 |
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AR siRNA |
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20-abx900461 | Abbexa |
|
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AR siRNA |
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20-abx908237 | Abbexa |
|
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AR siRNA |
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20-abx908238 | Abbexa |
|
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AR Antibody |
|||
DF6783 | Affbiotech | 200ul | 420 EUR |
AR Antibody |
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1-CSB-PA011255 | Cusabio |
|
|
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000 |
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AR Antibody |
|||
1-CSB-PA011256 | Cusabio |
|
|
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000 |
|||
AR Antibody |
|||
1-CSB-PA011257 | Cusabio |
|
|
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000 |
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AR Antibody |
|||
1-CSB-PA011258 | Cusabio |
|
|
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 |
|||
AR Antibody |
|||
1-CSB-PA006094 | Cusabio |
|
|
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000 |
|||
AR Antibody |
|||
1-CSB-PA056943 | Cusabio |
|
|
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:25-1:100 |
|||
AR Antibody |
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1-CSB-PA05979A0Rb | Cusabio |
|
|
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
|||
AR-A014418 |
|||
HY-10512 | MedChemExpress | 50mg | 410.4 EUR |
AR-9281 |
|||
HY-111151 | MedChemExpress | 5mg | 253.2 EUR |
AR-C155858 |
|||
HY-13248 | MedChemExpress | 10mM/1mL | 579.6 EUR |
AR-08 |
|||
HY-U00371 | MedChemExpress | 20mg | 16126.8 EUR |
AR 231453 |
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HY-15564 | MedChemExpress | 10mM/1mL | 192 EUR |
AR Antibody |
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F42684-0.4ML | NSJ Bioreagents | 0.4 ml | 322.15 EUR |
Description: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq]. |
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AR Antibody |
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F42850-0.4ML | NSJ Bioreagents | 0.4 ml | 322.15 EUR |
Description: The androgen receptor, also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding either of the androgenic hormones, testosterone, or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. It is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the AR is as a DNA-binding transcription factor that regulates gene expression; however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. [Wiki] |
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pCDNA3.1-AR |
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PVT18102 | Lifescience Market | 2 ug | 360 EUR |
Clematichinenoside AR |
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TBW00371 | ChemNorm | 10mg | 1016.4 EUR |
ar-Tumerone |
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TBW01373 | ChemNorm | 5mg | Ask for price |
Folic Acid |
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AT062 | Unibiotest | 1mg | 1134 EUR |
Folic acid |
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abx082263-100g | Abbexa | 100 g | 376.8 EUR |
Folic acid |
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20-abx082265 | Abbexa |
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Boric acid |
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abx082355-500g | Abbexa | 500 g | 243.6 EUR |
.A believable mannequin for this underlying distribution of phrase counts is given by means of modeling the DNA sequence as a Markov chain (MC). For single lengthy sequences, environment friendly statistics can be found to estimate the order of MCs and the transition chance matrix for the sequences. As NGS knowledge don’t present a single lengthy sequence, inference strategies on Markovian properties of sequences based mostly on single lengthy sequences can’t be instantly used for NGS quick learn knowledge.
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